Vanderbilt School of Medicine | Vanderbilt University | Vanderbilt Medical Center

Comparative Genomics

Comparative genomics enables scientists to compare large-scale genetic differences and similarities between different species and between sample members of the same species that differ in function or phenotype. In so doing, we can study gene content variation, gene function and their relationships. We are interested in the patterns that characterize the evolution and function of microbial infections of animals and plants. In particular, how does a symbiotic lifestyle affect abundance of mobile elements and host-interaction genes? How widesread is horizontal gene transfer between different cellular domains of life? Further, we use comparative genomics to invesitgate the evolution and function of bacteriophages in obligate intracellular bacteria.


Selected Publications:

Bordenstein SR and SR Bordenstein. (2016) Eukaryotic association module in phage WO genomes from Wolbachia. Nature Communications 7: 13155. Paper

Metcalf, JA, LJ Funkhouser, K Brileya, AL Reysenbach, SR Bordenstein (2014) Antibacterial gene transfer across the tree of life. eLife 3:e04266 Paper

Jernigan, KK and Bordenstein, SR (2014) Ankyrin domains across the tree of life PeerJ 2:e264. Paper

Funkhouser-Jones, L.J., S.R. Sehnert, P. Martinez-Rodriguez, R. Toribio-Fernandez, M. Pita, J.L. Bella and S.R. Bordenstein. (2015) Wolbachia co-infection in a hybrid zone: discovery of horizontal gene transfers from two Wolbachia supergroups into an animal genome (open access) PeerJ Paper

Newton, IL and Bordenstein, SR (2011) Correlations between bacterial ecology and mobile DNA. Current Microbiology 62(1): 198-208. Paper

Bordenstein, SR and Reznikoff WR (2005) Mobile DNA in obligate intracellular bacteria. Nature Reviews Microbiology 3, 688-699. Paper