Vanderbilt School of Medicine | Vanderbilt University | Vanderbilt Medical Center



Welcome to the Bordenstein laboratory

We endeavor to understand the principles that shape interactions between hosts, microbes, and viruses and the major consequences and applications of these interactions. Four key questions that drive basic and translational outcomes are:

  • How did life go from one to many millions of species today? How are microbial symbionts involved in the origin of animal species? Info | News | Pubs
  • How do viral genomes evolve and function in intracellular bacteria? Can this knowledge be applied to control mosquito-borne diseases? Info | News | Pubs
  • Will bioprospecting Archaea fuel discovery of new antibiotics? Publication | News
  • What is the evolutionary genetic and functional basis of animal x microbe interactions? Can this knowledge be applied to precision medicine initiatives? Info | News | Pubs


News & Events

Spring 2017 - Dylan Shropshire receives the NSF Graduate Research Fellowship and the Ann Bernard Martin Award for Excellence in Graduate Research, Kevin Kohl earns Honorable Mention for Vanderbilt Postdoc of the Year, Teddy Van Opstal receives Outstanding Student Abstract Award and a Travel Award at ASM Microbe 2017, Andrew Brooks recevied poster talk and Travel Award at ASM Microbe 2017. Hearty congratulations!

February 2017 - Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. One undergraduate co-author, Emily Layton, and collaboration with John Beckmann. Select coverage:


January 2017 - Establishment of F1 hybrid mortality in real time BMC Evolutionary Biology (open access) Three undergraduate co-authors and collaboration with the labs of Jeremy Lynch and Robert Brucker.

November 2016 - Phylosymbiosis: Relationships and functional effects of microbial communities across host evolutionary history PLOS Biology (open access) Select coverage:

October 2016 - Eukaryotic association module in phage WO genomes from Wolbachia. Nature Communications (open access). Select media at:

July 2016 - Fecal transplants: What is being transferred? PLOS Biology (open access)

April 2016 - Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. Collaboration with 15 biologists and philosophers. mSystems (open access)

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