Vanderbilt School of Medicine | Vanderbilt University | Vanderbilt Medical Center



Welcome to the Bordenstein laboratory

We endeavor to understand the principles that shape interactions between animals, microbes, and viruses and the basic and translational outcomes of these interactions. We employ hypothesis-driven approaches to study two forms of animal-microbe associations: intimate symbioses (between animals, obligate intracellular bacteria and bacteriophages) that impact animal reproduction and vector control, and facultative associations (between free-living organisms) that shape genome evolution across the tree of life. Our scholarship leverages a wide range of symbiosis expertise spanning virology, bacteriology, zoology, embryology, genetics, genomics, transcriptomics, ecology, evolution, development, and biochemistry.

Key questions that drive basic and translational outcomes are:



Recent News & Events

May 2018 - New publication at Current Biology. A maternal-effect, taxon-restricted gene in Nasonia controls titer of maternally transmitted Wolbachia.

May 2018 - New website launched for the Vanderbilt Microbiome Initiative (VMI)

April 2018 - New at Proceedings of the National Academy of Sciences. One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster.

January 2018 - New at Genome Biology and Evolution. Evolutionary genetics of cytoplasmic incompatibility genes cifA and cifB in prophage WO of Wolbachia. Collaboration with Irene Newton lab.

December 2017 - New at Molecular Ecology. Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Collaboration with Kevin Kohl and Denise Dearing.

February 2017 - Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. With undergraduate co-author, Emily Layton. Select coverage: