Vanderbilt School of Medicine | Vanderbilt University | Vanderbilt Medical Center



Welcome to the Bordenstein laboratory

We endeavor to understand the principles that shape interactions between hosts, microbes, and viruses and the major consequences and applications of these interactions. Four key questions that drive basic and translational outcomes are:

  • How did life go from one to many millions of species today? How is the microbiome involved in the processes of speciation? Info | News | Pubs
  • How do viral genomes evolve and function in intracellular bacteria? Info | News | Pubs
  • Will bioprospecting Archaea fuel discovery of new antibiotics? Publication | News
  • What is the relative importance of vertical and environmental transmission of the microbiome in animals? Info | News | Pubs


News & Events

February 2017 - Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. One undergraduate co-author, Emily Layton, and collaboration with John Beckmann. Select coverage:


January 2017 - Establishment of F1 hybrid mortality in real time. BMC Evolutionary Biology (open access). 3 undergraduate co-authors and collaboration with Jeremy Lynch and Robert Brucker.

November 2016 - Phylosymbiosis: Relationships and functional effects of microbial communities across host evolutionary history PLOS Biology (open access) Select coverage:

October 2016 - Eukaryotic association module in phage WO genomes from Wolbachia. Nature Communications (open access). Select media at:

September 2016 - Disentangling a holobiont - Recent advances and perspectives in Nasonia wasps. Frontiers in Microbiology (open access).

July 2016 - Fecal transplants: What is being transferred? PLOS Biology (open access)

April 2016 - Getting the Hologenome Concept Right: An Eco-Evolutionary Framework for Hosts and Their Microbiomes. Collaboration with 15 biologists and philosophers. mSystems (open access)

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