Vanderbilt School of Medicine | Vanderbilt University | Vanderbilt Medical Center



Welcome to the Bordenstein laboratory

We endeavor to understand the principles that shape interactions between hosts, microbes, and viruses as well as the major consequences and applications of these interactions. Four key questions that drive basic and translational outcomes are:

  • How did life go from one to many millions of species today? How do microbes impact the origin of new animal species? Info | News | Pubs
  • How do viral genomes evolve and function in intracellular bacteria (Wolbachia)? Can this knowledge be applied to control mosquito-borne diseases? Info | News | Pubs
  • Will bioprospecting Archaea fuel discovery of new antibiotics? Publication | News
  • What is the evolutionary genetic and functional basis of animal x microbe interactions? Can this knowledge be applied to precision medicine initiatives? Info | News | Pubs



News & Events

May 2018 - New publication at Current Biology. A maternal-effect, taxon-restricted gene in wasps controls titer of maternally transmitted Wolbachia.

May 2018 - New website launched for the Vanderbilt Microbiome Initiative (VMI)

April 2018 - New at Proceedings of the National Academy of Sciences. One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster.

January 2018 - New at Genome Biology and Evolution. Evolutionary genetics of cytoplasmic incompatibility genes cifA and cifB in prophage WO of Wolbachia. Collaboration with Irene Newton lab.

December 2017 - New at Molecular Ecology. Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Collaboration with Kevin Kohl and Denise Dearing.

February 2017 - Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature. With undergraduate co-author, Emily Layton. Select coverage: